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Paper Published: Bioabsorbable Fish Scale for the Internal Fixation of Fracture: A Preliminary Study
Volume 20, Numbers 17 and 18, 2014
@ Mary Ann Liebert, Inc.
DOI: 10.1089/ ten. tea. 2013. 0174

Bioabsorbable Fish Scale for the Internal Fixation of Fracture: A Preliminary Study

Cheng-Hung Chou, PhD,  Yong-Guei Chen, PhD,  Chien-Chen Lin, PhD,  
Shang-Ming Lin, PhD,  Kai-Chiang Yang, PhD,  and Shih-Hsin Chang, MD, PhD.


Fish scales, which consist of type I collagen and hydroxyapatite (HA), were used to fabricate a bioabsorbable bone pin in
this study. Fresh fish scales were decellularized and characterized to provide higher biocompatibility. The mechanical
properties of fish scales were tested, and the microstructure of an acellular fish scale was examined. The growth curve of
a myoblastic cell line (C2C12), which was cultured on the acellular fish scales, implied biocompatibility in vitro, and the
morphology of the cells cultured on the scales was observed using scanning electron microscopy (SEM). A bone pin
made of decellularized fish scales was used for the internal fixation of femur fractures in New Zealand rabbits. Periodic
X-ray evaluations were obtained, and histologic examinations were performed postoperatively. The present results
show good cell growth on decellularized fish scales, implying great biocompatibility in vitro. Using SEM, the cell
morphology revealed great adhesion on a native, layered collagen structure. The Young’s modulus was 332 – 50.4 MPa
and the tensile strength was 34.4 – 6.9 MPa for the decellularized fish scales. Animal studies revealed that a fish-scale-
derivedbone pin improved thehealing of bone fractures and degraded withtime. Afteran8-weekimplantation,thebone
pin integrated with the adjacent tissue, and new extracellular matrix was synthesized around the implant. Our results
proved that fish-scale-derived bone pins are a promising implant material for bone healing and clinical applications.

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Last updated on:2019-11-27