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A meta-analysis on ologen Collagen Matrix vs MMC in Trabeculectomy to be highlighted at the 2014 AGS Exhibit
2014-02-07
A meta-analysis on ologen Collagen Matrix vs. MMC in trabeculectomy by Miao He et al. (2014) will be highlighted during the exhibit of AAE at the 2014 AGS, Washington DC at Omni Shoreham Hotel from Feb 27 - Mar 1. We sincerely welcome your visit at our booth T12.

The meta-analysis with the inclusion of the seven (7) RCTs including 227 eyes has shown that the WMDs (weighted mean difference) in IOP reduction between the ologen group and the MMC group in trabeculectomy were not significantly different in the follow-up period of 3m, 6m, 24m; the complete/qualified success rates 
(defined as post-op IOP < 21 mmHg w/o Rx; w/ or w/o Rx) of the two groups were also comparable at all time points. The meta-analysis reconciled the differences in the interpretations of the RCTs in terms of analyzing the absolute IOP vs. the reduction in IOP (which should be the case as a set of pre-/post-op IOP is considered paired data) by conducting a series of sensitivity tests, assessing for the review quality (kappa test), testing for publication bias (funnel plot and Egger's test) and adjusting for study heterogeneity (a random effect model despite no Chi-square, I-square test findings) according to a good review practice (the Cochrane Reviewer’s Handbook and the PRISMA).

Further large-scale RCTs from the US and RCTs with follow-up up to 5 years from the EU are expected to be presenting at the "ologen Lunch Symposium" (Apr 3; Hall D5) at the 2014 WOC Tokyo from Apr 2 - Apr 5 along with the other topics of the novel application of ologen Collagen Matrix in bleb revision surgery and the repair of scleromalacia. We are also looking forward to meeting you at the April event.
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